Product Description

OAZ3 Polyclonal Antibody

Catalogue Numbers: BS60197-50, BS60197-100

Sizes: 50µl, 100µl

Alternative Name: Ornithine decarboxylase antizyme 3; AZ3; ODC-Az 3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UMX2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The antizyme family is a group of small proteins that play a role in cell growth and division by regulating the biosynthesis of polyamines such as putrescine, spermidine and spermine. AZ3, also known as OAZ3 (Ornithine decarboxylase antizyme 3), is a 187 amino acid protein that belongs to the ODC antizyme family. AZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells because it binds to, and destabilizes, ornithine decarboxylase. However, mutations in the AZ3 gene are not a common cause of male infertility and the normal AZ3 protein does not accelerate ornithine decarboxylase degeneration. AZ3 expression has a sharp onset in early spermatids, peaks in later stages and is gone in spermatozoa.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OAZ3 polyclonal antibody detects endogenous levels of OAZ3 protein.

Bioworld Molecular Weight: ~ 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of OAZ3 polyclonal antibody at 1:500 dilution
Lane 1: Jurkat whole cell lysate
Lane 2: Mouse testis tissue lysate
Lane 3: Rat testis tissue lysate

Immunogen: A synthetic peptide corresponding to residues in Human OAZ3.

Conjugate: Unconjugated

Modification: Unmodified