Ob-R (phospho Tyr1141) rabbit pAb - ES1533

Ob-R (phospho Tyr1141) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1533-50, ES1533-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010],

Alternate Name: LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD antigen CD295

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Ob-R (phospho Tyr1141)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 132kD

Human Gene ID: 3953

Human SWISS Prot NO: P48357

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.; [Isoform E]: Secreted.

Research Use Only