Ob-R Polyclonal Antibody - BT-AP06325

Ob-R Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06325-20, BT-AP06325-50, BT-AP06325-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by LEPR belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID: 54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID: 9207021).

Research Areas: Signal Transduction

Target Protein: LEPR

Applications: WB, IHC-p, ELISA

Reactivity: Human, Mouse, Monkey

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Ob-R Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 132494

UniProt Accession: Human: P48357; Mouse: P48356

Synonyms: LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD antigen CD295

GeneID: Human: 3953; Mouse: 16847

Research Use Only