Oct-3/4 Monoclonal Antibody - RA10634

Oct-3/4 Monoclonal Antibody Size: 50μL, 100μL Catalogue Numbers: RA10634-50, RA10634-100 Citations, Manuals and MSDS Available upon request. Background: POU class 5 homeobox 1 (POU5F1) Homo sapiens This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013], Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Storage Instructions: -20°C/1 year Applications: WB; FCM; IF/ICC Species Cross-Reactivity: Human GeneID (Human): 5460 SWISS: Q01860 Source: Mouse Research Use Only