OCT-4 Monoclonal Antibody - BT-MCA4034

OCT-4 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4034-50, BT-MCA4034-100

Citations, Manuals and MSDS Available upon request.

Background: Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.

Research Areas: Others

Target Protein: OCT-4

Reactivity: Human

Clonality: Monoclonal

Clone ID: 1D10H6

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: OCT-4

Immunogen: Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 38.5kDa

UniProt Accession: Q01860

Synonyms: OCT3, OTF3, OTF4, MGC22487, POU5F1

GeneID: 5460

Research Use Only