OCT4 Monoclonal Antibody-MB66483

OCT4 Monoclonal Antibody

Catalogue Numbers: MB66483-50, MB66483-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: P20263

Host: Mouse

Reactivity: Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Oct-4 (POU5F1) is a transcription factor highly expressed in undifferentiated embryonic stem cells and embryonic germ cells. A network of key factors that includes Oct-4, Nanog, and Sox2 is necessary for the maintenance of pluripotent potential, and downregulation of Oct-4 has been shown to trigger cell differentiation. Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker . Oct-4 exists as two splice variants, Oct-4A and Oct-4B. Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency, while Oct-4B may exist in some somatic, non-pluripotent cells.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of 44838 protein.

Extra Notes: Western blot analysis of 44838 expression in F9 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: OCT3; OCT4; OTF3; POU domain class 5 transcription factor 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3

Immunogen: Purified recombinant mouse POU5F1/OCT4 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified