OGG1 Polyclonal Antibody - BT-AP12189

OGG1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12189-20, BT-AP12189-50, BT-AP12189-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Research Areas: Cancer; Epigenetics and nuclear signaling

Target Protein: OGG1

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O15527; Mouse: O08760; Rat: O70249

Synonyms: N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase;EC 3.2.2.-; DNA-;apurinic or apyrimidinic site lyase;AP lyase;EC 4.2.99.18]

GeneID: Human: 4968

Research Use Only