Product Description

OLFM2 Recombinant Rabbit mAb

Sizes: 50μl, 100μl

Catalogue Numbers: BS48514-50, BS48514-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regμlator of vascμlar smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascμlar SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimμli. SMC phenotypic plasticity is essential for vascμlar development and remodeling (By similarity).

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC, ICC/IF

Alternate Names: NOE2, OlfC, NOELIN2, NOELIN2_V1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide of human OLFM2

Dilution: WB: 1:1000 IHC: 1:100 ICC/IF: 1:50

Purification: Affinity Purification

Specificity: IgG

Molecular Weight: 49 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95897

Product: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Research Use Only