Product Description

OSGEPL1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS71054-50, BS71054-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H4B0

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

All Applications: WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100

Background: OSGEPL1, also known as Qri7, is a 414 amino acid protein that belongs to the KAE1/YgjD family and exists as 3 alternatively spliced isoforms. In tRNAs that have codons beginning with adenine, OSGEPL1 is required for the formation of a threonylcarbamoyl group on adenosine. The gene that encodes OSGEPL1 contains about 16,568 bases and maps to human chromosome 2q32.2. Consisting of 237 million bases, chromosome 2 encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5
and ABCG8. An extremely rare recessive genetic disorder, Alström syndrome, is due to mutations in the ALMS1 gene

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: OSGEPL1 polyclonal antibody detects endogenous levels of OSGEPL1 protein.

Bioworld Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of various cells, using OSGEPL1 antibody., Immunohistochemistry of paraffin-embedded human liver injury using OSGEPL1 antibody at dilution of 1:100 (x40 lens)., Immunohistochemistry of paraffin-embedded rat brain using OSGEPL1 antibody at dilution of 1:100 (x40 lens).

Alternative Name: GCP1; t(6)A synthase

Immunogen: Recombinant protein of human OSGEPL1.

Conjugate: Unconjugated

Modification: Unmodified