Product Description

OTX2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66966-50, MB66966-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Orthodenticle homeobox 2 (OTX2) belongs to the bicoid subfamily of paired-box, homeodomain-containing transcription factors. OTX2 is a critically important neuronal transcription factor that functions to regμlate the expression of cell cycle genes controlling proliferation and differentiation of neural progenitor cells . In addition to its neuronal development functions, it has been reported that OTX2 can function in a non-cell autonomous manner to promote survival of damaged retinal ganglion cells . OTX2 has also been shown to influence the susceptibility of post-mitotic neurons to toxic insμlt or physiological stress . Notably, aberrant expression of OTX2 has been strongly linked with neuronal tumor development. For example, research studies have found OTX2 is overexpressed in many medμlloblastoma cell lines, and both overexpression and gene amplification were reported in a subset of primary medμlloblastomas . In vitro studies support these observations, as targeted alterations in OTX2 expression directly affected both proliferation and senescence of medμlloblastoma cell lines .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Homeobox protein OTX2, Orthodenticle homolog 2

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human OTX2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of OTX2 protein.

Molecular Weight: ~ 33 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P32243

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only