P-glycoProtein 1 Polyclonal Antibody-BS71461

P-glycoProtein 1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS71461-50, BS71461-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P08183

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IF

All Applications: WB 1:500 - 1:2000
IF 1:50 - 1:200

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: P-glycoprotein 1 polyclonal antibody detects endogenous levels of P-glycoprotein 1 protein.

Bioworld Molecular Weight: ~ 150 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extracts of various cell lines, using P-glycoprotein 1 antibody.

Alternative Name: Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1; P-gp

Immunogen: A synthetic peptide of human P-glycoprotein 1

Conjugate: Unconjugated

Modification: Unmodified