p107 (phospho Thr369) rabbit pAb - ES7011

p107 (phospho Thr369) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7011-50, ES7011-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms hav

Alternate Name: RBL1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human RBL1 around the phosphorylation site of Thr369. AA range:335-384

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5933

Human SWISS Prot NO: P28749

Subcellular Location: Nucleus

Research Use Only