Product Description

p130 Cas (phospho-Y410) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4244-50, BS4244-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The p130Cas (Cas for Crk-associated substrate) is a common cellμlar target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by mμltiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimμlation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascμlar development, actin filament assembly and Src-induced cell transformation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, Cas scaffolding protein family member 1, p130cas, BCAR1, CAS, CASS1, CRKAS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human p130 Cas around the phosphorylation site of Tyrosine 410.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-p130 Cas (Y410) polyclonal antibody detects endogenous levels of p130 Cas protein only when phosphorylated at Tyr410.

Molecular Weight: ~ 130 kDa

Pathway: Regμlation of Actin Dynamics, ErbB HER Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56945

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only