p15 Polyclonal Antibody - BT-AP06743

p15 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06743-20, BT-AP06743-50, BT-AP06743-100

Citations, Manuals and MSDS Available upon request.

Background: CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus cyclin dependent kinase inhibitor 2B functions as a cell growth regulator that controls cell cycle G1 progression. The expression of CDKN2B was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of CDKN2B, which encode distinct proteins, have been reported.

Research Areas: Cell Biology

Target Protein: CDKN2B

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: p15 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 14722

UniProt Accession: Human: P42772; Mouse: P55271; Rat: P55272

Synonyms: CDKN2B; MTS2; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; p15INK4B

GeneID: Human: 1030; Mouse: 12579; Rat: 25164

Research Use Only