Product Description

p23 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90999-50, BS90999-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15185(Human) Q9R0Q7(Mouse) P83868(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC, IHC, IP,

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:100-1:500
IP:1:10-1:50

Background: P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ERα), a steroid complex, to its mature form and to regulate the expression of ERα-related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: p23 polyclonal antibody detects endogenous levels of p23 protein.

Bioworld Molecular Weight: 23 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of p23 on different lysates using anti-p23 antibody at 1/500 dilution.
Positive control:
Lane 1: Mouse brain tissue
Lane 2: SK-Br-3
Lane 3: Rat lung tissue, ICC staining p23 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: cPGES, PTGES3, P23, TEBP, Co chaperone p23, cPGES, Cytosolic prostaglandin E synthase, Cytosolic prostaglandin E2 synthase, Hsp90 co chaperone, Hsp90 co-chaperone, P23, Progesterone receptor complex, Progesterone receptor complex p23, Prostaglandin E synthase 3 (cytosolic), Prostaglandin E synthase 3, PTGES 3, PTGES3, Sid 3177, TEBP, TEBP, Telomerase binding protein p23, Telomerase-binding protein p23, Unactive progesterone receptor 23 kD,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified