P3C2B Polyclonal Antibody - BT-AP12645

P3C2B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12645-20, BT-AP12645-50, BT-AP12645-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Research Areas: Immunology; Signal transduction

Target Protein: PIK3C2B

Applications: WB, ELISA

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: O00750

Synonyms: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta;PI3K-C2-beta;PtdIns-3-kinase C2 subunit beta;EC 2.7.1.154;C2-PI3K;Phosphoinositide 3-kinase-C2-beta

GeneID: Human: 5287

Research Use Only