Product Description

P4HB Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS6048-50, BS6048-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P07237

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC, IF

All Applications: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: Oxidoreductase-protein disulfide isomerase (PDI) is a homodimer consisting of subunits that catalyzes thiol-disulfide exchange, mediates folding of newly synthesized proteins and functions as a molecular chaperone. PDI localizes to the lumen of the endoplasmic reticulum (ER), where in conjunction with folding-helper proteins, such as immunoglobulin heavy chain binding protein (BiP), mediates tertiary and quaternary protein-processing. Cell surface PDI induces sulfhydryl-mediated conformational changes in integrin-mediated adhesion receptor-ligand interactions, thereby regulating integrin responses and cell adhesion. Additionally, PDI functions as a subunit of two more complex enzyme systems: the prolyl-4-hydroxylase and the triacylglycerol transfer proteins.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: P4HB polyclonal antibody detects endogenous levels of P4HB protein.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: WesternBlot (WB) analysis of P4HB polyclonal antibody, Immunofluorescence analysis of Hela cells, using P4HB polyclonal antibody

Alternative Name: Cellular thyroid hormone binding protein;
Cellular thyroid hormone-binding protein;
Collagen prolyl 4 hydroxylase beta;
Disulphide Isomerase;
DSI;
EC 5.3.4.1;
Endoplasmic reticulum resident protein 59;
ER protein 59;
ERBA2L;
ERp59;
GIT;
Gltathione insulin transhydrogenase;
Glutathione insulin transhydrogenase;
P4HB;
P4Hbeta;
p55;
PDI;
PDIA1;
PDIA1;
PDIR;
PHDB;
PO4DB;
PO4HB;
Procollagen proline 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase) beta polypeptide (pro

Immunogen: Recombinant full length Human P4HB.

Conjugate: Unconjugated

Modification: Unmodified