p53DINP1 Polyclonal Antibody-BS91005

p53DINP1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91005-50, BS91005-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q96A56(Human)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IF, IHC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: p53DINP1 polyclonal antibody detects endogenous levels of p53DINP1 protein.

Bioworld Molecular Weight: 27 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of p53DINP1 on different cell lysates using anti-p53DINP1 at 1/500 dilution.
Positive control:
Line 1: SH-SY-5Y
Line 2: HepG2
Line 3: Mouse stomach
Line 3: Human stomach, ICC staining p53DINP1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: p53DINP1, TP53INP1, P53DINP1, SIP, DKFZp434M1317, FLJ22139, p53 damage inducible nuclear protein 1, p53 dependent damage inducible nuclear protein 1, p53 inducible nuclear protein 1, p53 inducible p53DINP1, p53-dependent damage-inducible nuclear protein 1, p53DINP1, SIP, Stress induced protein, Stress-induced protein, T53I1, Teap, TP53 DINP1, TP53 INP1, TP53DINP1, TP53INP1, TP53INP1A, TP53INP1B, Tumor protein p53 inducible nuclear protein 1, Tumor protein p53-inducible nuclear protein 1,

Immunogen: Full length recombinant protein of human p53DINP1.

Conjugate: Unconjugated

Modification: Unmodified