Product Description

p53RFP Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28418-50, RA28418-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family., domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme., function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism., pathway:Protein modification; protein ubiquitination., PTM:Auto-ubiquitinated., similarity:Belongs to the RBR family. RNF144 subfamily., similarity:Contains 1 IBR-type zinc finger., similarity:Contains 2 RING-type zinc fingers., subunit:Interacts with UBE2L3, UBE2L6 and LCMT2., tissue specificity:Broadly expressed, with lowest levels in brain, spleen and thymus.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: RNF144B, IBRDC2, P53RFP, E3 ubiquitin-protein ligase RNF144B, IBR domain-containing protein 2, RING finger protein 144B, p53-inducible RING finger protein

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 35

Protein Molecular Weight (kDa): 35

Storage: -20°C/1 year

Human Gene ID: 255488

Human SwissProt Number: Q7Z419

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only