p57 rabbit pAb - ES4072

p57 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4072-50, ES4072-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],

Alternate Name: CDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2

Source: Rabbit

Applications: WB; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human p57Kip2 around the non-acetylation site of Lys278. AA range:241-290

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 32kD

Human Gene ID: 1028

Human SWISS Prot NO: P49918

Subcellular Location: Nucleus

Research Use Only