Product Description

p63 (N662) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1279-50, BS1279-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regμlator of cell growth in response to DNA damage. p73 shares a high degree of homology with p53, and appears to have similar growth-inhibiting and apoptosis-promoting functions. However, unlike p53, the expression of p73 is not upregμlated in response to DNA damage. p73 can, when overproduced, activate the p53- responsive gene p21. p63 has also been identified based on its similarities with p53. The p63 gene encodes mμltiple isotypes with variable functions. p63α (also designated p51B or KET), p63β and p63γ (also designated p51A), as well as corresponding TA* p63 isoforms, contain transactivation domains which have been shown to transactivate p53 reporter genes and induce apoptosis. p63 isoforms lack the transactivation domain and can act as dominant- negative reagents to inhibit transactivation by p53 and p63.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Tumor protein 63, Chronicμlcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 634-680 of Human p63.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p63 (N662) polyclonal antibody detects endogenous levels of p63 protein.

Molecular Weight: ~ 77 kDa

Pathway: Cell Cycle G2 M DNA Damage Signaling Pathway,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9H3D4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only