Product Description

p73 (phospho-Y99) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4152-50, BS4152-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: p73 protein is a member of the p53 family of proteins. The tumor-suppressor protein p53 exhibits sequence specific DNA binding, directly interacts with various cellμlar and viral proteins, and induces cell cycle arrest in response to DNA damage. In response to signals generated by a variety of genotoxic stresses, e.g, UV irradiation or DNA damage, p53 is expressed and undergoes post translational modification that resμlts in its accumμlation in the nucleus. Activation of p53 leads to cell cycle arrest and in some cases to apoptosis, resμlting in the inability of genetically damaged cells to proliferate. Thus, the p53 dependent pathways help to maintain genomic stability by eliminating damaged cells. The accumμlation of high levels of p53 is a potential marker for malignancy. p73 protein is expressed in either fμll length form (p73 alpha 80 kDa) or a shorter (p73 beta 70 kDa) mRNA variant. p73 gene was predicted to encode a protein with significant amino acid sequence similarity to p53. Each of the p53 amino acid residues implicated in direct sequence specific DNA binding is conserved in p73.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC

Alternate Names: p73, p53-like transcription factor, p53-related protein, p73, P73

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human p73 around the phosphorylation site of Tyrosine 99.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-p73 (Y99) polyclonal antibody detects endogenous levels of p73 protein when phosphorylated at Tyr99.

Molecular Weight: ~ 73 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15350

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only