PAF-R rabbit pAb - ES6880

PAF-R rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6880-50, ES6880-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Alternate Name: PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr

Source: Rabbit

Applications: IF; ELISA

Dilution: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human PTAFR. AA range:194-243

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5724

Human SWISS Prot NO: P25105

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Research Use Only