PALLD Polyclonal Antibody
Catalogue Numbers: BS60777-50, BS60777-100
Sizes: 50µl, 100µl
Alternative Name: Palladin; SIH002; Sarcoma antigen NY-SAR-77; PALLD; KIAA0992; CGI-151
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q8WX93
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Palladin, also known as PALLD, PNCA1 or SIH002, is a 1,383 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains five immunoglobulin (Ig)-like domains. Expressed as several alternatively spliced isoforms that are found in kidney, prostate, ovary and colon, palladin functions as a cytoskeletal protein that is required both for the organization of the Actin cytoskeleton, as well as for the establishment of proper cell motility, cell adhesion and cell-matrix interactions. Palladin interacts with Eps8, LASP-1 and VASP and may also play a role in cytoskeletal scaffolding and Actin remodeling. In response to DNA damage, palladin is subject to phosphorylation on select serine residues. Defects in the gene encoding palladin may increase genetic susceptibility to pancreatic cancer, strongly suggesting a role for palladin in tumorigenesis.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: PALLD polyclonal antibody detects endogenous levels of PALLD protein.
Bioworld Molecular Weight: ~ 151 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of PALLD polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human PALLD
Conjugate: Unconjugated
Modification: Unmodified