Pan glycine myristoylation Polyclonal Antibody - BT-AP12765

Pan glycine myristoylation Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12765-20, BT-AP12765-50, BT-AP12765-100

Citations, Manuals and MSDS Available upon request.

Background: Pan3 (PAB-dependent poly(A)-specific ribonuclease subunit 3) is a 741 amino acid cytoplasmic protein belonging to the protein kinase superfamily. Containing a protein kinase domain, Pan3 is a component of the Pan nuclease complex and recruits polyadenylate-binding protein, which in turn stimulates Pan2 nuclease activity. It is suggested that Pan3 may have a functional role in cytoplasmic mRNA decay. Pan3 exists as three isoforms produced by alternative splicing and the gene encoding Pan3 is located on human chromosome 13. Chromosome 13 houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

Research Areas: Signal transduction; Epigenetics and nuclear signaling; Metabolism

Applications: WB, ELISA

Reactivity: Species independent

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Research Use Only