Product Description

PAOX Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28509-50, RA28509-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:N (1), N (12)-diacetylspermine + O (2) + H (2)O = N (1)-acetylspermidine + 3-acetamidobutanal + H (2)O (2)., catalytic activity:N (1)-acetylspermidine + O (2) + H (2)O = putrescine + 3-acetamidopropanal + H (2)O (2)., catalytic activity:N (1)-acetylspermine + O (2) + H (2)O = spermidine + 3-acetamidopropanal + H (2)O (2)., cofactor:Binds 1 FAD per subunit., function:Flavoenzyme which catalyzes the oxidation of N (1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N (1)-acetylspermidine to putrescine. Substrate specificity: N (1)-acetylspermine = N (1)-acetylspermidine > N (1), N (12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs., induction:By polyamine analogs., miscellaneous:Oxidizes N (1)-acetylated polyamines on the exo-side of their N (4)-amino groups. Plant PAO oxidizes spermine on the endo-side of the N (4)-nitrogen., pathway:Amine and polyamine metabolism; spermine metabolism., similarity:Belongs to the flavin monoamine oxidase family., subunit:Monomer., tissue specificity:Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: PAOX, PAO, Peroxisomal N (1)-acetyl-spermine/spermidine oxidase, Polyamine oxidase

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight: 70

Protein Molecular Weight (kDa): 70

Storage: -20°C/1 year

Human Gene ID: 196743

Human SwissProt Number: Q6QHF9

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only