PAR4 Rabbit pAb - A3063

PAR4 Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A3063-20, A3063-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 37kDa

Observed Molecular Weight: 43kDa

Immunogen: Synthetic peptide .

Species: Human

GeneID: 5074

SWISS: Q96IZ0

Alternate Names: PAR4; Par-4

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:2000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Cell Biology Developmental Biology, Apoptosis, Cell Cycle, Endocrine Metabolism.

NCBI Alias: PAWR

Research Use Only