PAR4 rabbit pAb - ES3147

PAR4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3147-50, ES3147-100

Citations, Manuals and MSDS Available upon request.

Background: The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008],

Alternate Name: PAWR; PAR4; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat; Cow

Immunogen: The antiserum was produced against synthesized peptide derived from human Prostate Apoptosis Response protein-4. AA range:291-340

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 36kD

Human Gene ID: 5074

Human SWISS Prot NO: Q96IZ0

Subcellular Location: Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies.

Research Use Only