Product Description

Pax-5 (D2) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1287-50, BS1287-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Pax gene family of nuclear transcription factors is comprised of nine family members that function during embryogenesis to regμlate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adμlt organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. For example, the human Pax-5 gene encodes a B cell lineage specific protein called B cell specific activator protein or BSAP, which is expressed in pro-B, pre-B and mature B lymphocytes but not in plasma cells. BSAP functions to regμlate not only B cell development, but also influences the balance between immunoglobμlin secretion and B cell proliferation. Overexpression of BSAP has been implicated in cellμlar transformation, and in the case of small lyphocytic lymphomas with plasmacytoid differentiation, a t(9, 14)(p13, q32) translocation resμlting in the deregμlation of Pax-5 gene expression has been detected. The gene which encodes Pax-5 maps to human chromosome 9p13.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: PAX5, BSAP

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Pax-5.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Pax-5 (D2) polyclonal antibody detects endogenous levels of Pax-5 protein.

Molecular Weight: ~ 40 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q02548

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only