Pax-5 Polyclonal Antibody - BT-AP06948

Pax-5 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06948-20, BT-AP06948-50, BT-AP06948-100

Citations, Manuals and MSDS Available upon request.

Background: PAX5 encodes a member of the paired box (PAX) family of transcription factors. The central feature of PAX5 family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of PAX5 are thought to contribute to neoplastic transformation. PAX5 encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the paired box 5 may also play a role in neural development and spermatogenesis. PAX5 is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of PAX5 contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

Research Areas: Neuroscience

Target Protein: PAX5

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Pax-5 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 42149

UniProt Accession: Human: Q02548; Mouse: Q02650

Synonyms: PAX5; Paired box protein Pax-5; B-cell-specific transcription factor; BSAP

GeneID: Human: 5079; Mouse: 18507

Research Use Only