Product Description

PAX6 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66947-50, MB66947-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Paired box (PAX) proteins are a family of transcription factors that play important and diverse roles in animal development . Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an amino-terminal "paired" domain, consisting of two helix-turn-helix motifs, with DNA binding activity . PAX proteins are classified into four structurally distinct subgroups (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but lacks the homeodomain, subgroup II (PAX2, 5, and 8) contains the octapeptide and a truncated homeodomain, subgroup III (PAX3 and 7) contains the octapeptide and a complete homeodomain, and subgroup IV (PAX4 and 6) contains a complete homeodomain but lacks the octapeptide region . PAX proteins play critically important roles in development by regμlating transcriptional networks responsible for embryonic patterning and organogenesis , a subset of PAX proteins also maintain functional importance during postnatal development . Research studies have implicated genetic mutations that resμlt in aberrant expression of PAX genes in a number of cancer subtypes , with members of subgroups II and III identified as potential mediators of tumor progression . Pax6 has important functions in organ development. It is a key regμlator of eye development , and mutations in Pax6 have been associated with some forms of aniridia, a congenital malformation of the eye . Pax6 is also involved in neuronal development, which plays an especially important role in corticogenesis . Within its role in the adμlt brain, it has recently been associated with aging, with gene occupancy studies showing increased association of Pax6 with genes associated with many aging processes in mice . Pax6 also plays another important function in development and maintenance of pancreatic β-cells . Driven by expression of Pdx1, both Pax6 and NGN3 expression is required for β-cell identity .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IF/ICC

Alternate Names: AN2, Paired box protein Pax-6, Aniridia type II protein, Ocμlorhombin

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human PAX6. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/4000), IF/ICC (1/10 - 1/50)

Specificity: Recognizes endogenous levels of PAX6 protein.

Molecular Weight: ~ 50 kDa

Pathway: MAPK Erk in Growth and Differentiation Pathway.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P26367

Product: Mouse IgM kappa. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only