PAX6 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91024-50, BS91024-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P26367(Human) P63015(Mouse) P63016(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC
All Applications: WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
Background: Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PAX6 polyclonal antibody detects endogenous levels of PAX6 protein.
Bioworld Molecular Weight: 48 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of PAX6 on Hela cells lysates using anti-PAX6 antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat eyeball tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Alternative Name: PAX6, AN 2, AN, AN2, Aniridia type II protein, D11S812E, FVH1, KIAA0552, Leucine zipper putative tumor suppressor 3, LZTS3, MGC17209, MGDA, Oculorhombin, Paired box 6, Paired box gene 6 (aniridia keratitis), Paired Box Gene 6, Paired box homeotic gene 6, Paired box protein Pax-6, Paired box protein Pax6, PAX 6, PAX6, PAX6, ProSAP-interacting protein 1, PROSAPIP1, Sey, WAGR,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified