Product Description

Paxillin (Q82) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3183-50, BS3183-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Paxillin is a focal adhesion phosphoprotein that is localized to the cytoskeleton. FAK phosphorylates paxillin specifically on Tyr 118 in vitro. However, FAK phosphorylation does not seem to be required for the recruitment of paxillin to cell adhesion sites. Paxillin may play a role in signal transduction, regμlation of cell morphology and the recruitment of structural and signaling molecμles to focal adhesions. It has been shown that the amount of paxillin is reduced in mitotic cells by proteolytic downregμlation and that paxillin is alternatively phosphorylated on serine rather than on tyrosine and serine during mitosis.

Category: Primary Antibody

Reactivity: Human, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: PXN

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human Paxillin.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Paxillin (Q82) polyclonal antibody detects endogenous levels of Paxillin protein.

Molecular Weight: ~ 65 kDa

Pathway: Regμlation of Actin Dynamics, Tumor Angiogenesis, Contribution of ECM and Cytoskeletal Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P49023

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only