PBR Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91032-50, BS91032-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P30536(Human) P50637(Mouse)
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, IHC
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
Background: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
Purification and Purity: Protein affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PBR polyclonal antibody detects endogenous levels of PBR protein.
Bioworld Molecular Weight: 10/18 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of PBR on A431 and PC-3M cell lysateS using anti-PBR antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PBR antibody. Counter stained with hematoxylin.
Alternative Name: PBR, TSPO, BZRP, MBR, Benzodiazapine receptor (peripheral), Benzodiazepine peripheral binding site, BPBS, BZRP, DBI, IBP, Isoquinoline carboxamide-binding protein, MBR, mDRC, Mitochondrial benzodiazepine receptor, PBR, PBS, Peripheral benzodiazepine receptor, Peripheral benzodiazepine receptor-related protein, Peripheral type benzodiazepine receptor, Peripheral-type benzodiazepine receptor, pk18, PKBS, PTBR, Ptbzr, PTBZR02, RATPTBZR02, translocator protein (18kDa), Translocator protein, Tspo, Tspo1, TSPOA,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified