PCB Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA21425-50, RA21425-100 Citations, Manuals and MSDS Available upon request. Background: pyruvate carboxylase (PC) Homo sapiens This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications. Alternative Names: PC; Pyruvate carboxylase; mitochondrial; Pyruvic carboxylase; PCB Applications: WB; IHC-p; IF/ICC; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 5091 Protein MW (KDa): 120 SWISS: P11498 Source: Rabbit Research Use Only