PCB Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA21425-50, RA21425-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: pyruvate carboxylase (PC) Homo sapiens This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008], Reactivity: Human, Mouse, Rat Host: Rabbit Applications: WB, IHC-p, IF/ICC, ELISA Alternate Names: PC, Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications. Molecular Weight: 120 Protein Molecular Weight (kDa): 120 Storage: -20°C/1 year Human Gene ID: 5091 Human SwissProt Number: P11498 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only