PCDA8 Rabbit Polyclonal Antibody - BT-AP11818

PCDA8 Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11818-20, BT-AP11818-50, BT-AP11818-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the protocadherin alpha gene cluster| one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons| or variable exons| are followed by downstream C-terminal exons| or constant exons| which are shared by all genes in the cluster. The large| uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Research Areas: Neuroscience; Signal transduction

Target Protein: PCDHA8

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: PCDA8

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9Y5H6

Synonyms: PCDA8; Protocadherin alpha-8; PCDH-alpha-8

GeneID: Human: 56140

Research Use Only