PCK1 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91034-50, BS91034-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P35558(Human)
Host: Rabbit
Reactivity: Human
Applications: ICC IHC WB,
All Applications: ICC:1:50-1:200
IHC:1:50-1:200
WB:1:500
Background: Normal adjustment to changes in blood glucose levels depends on insulin signaling as well as enzymes involved in the regulation of gluconeogenesis. Pathological changes to this process are central to the type 2 diabetes phenotype. Phosphoenolpyruvate carboxykinase (PEPCK) plays an important role in this process by stimulating hepatic glucose production. PEPCK expression increases in response to glucagon and glucocorticoids, while insulin suppresses expression. Modulation of the signals governing PEPCK levels present a potential therapeutic approach to the treatment of insulin resistance and consequently obesity. The cytosolic form of PEPCK, known as PEPCK-C, and the mitochondrial form, known as PEPCK-M, are encoded by two different nuclear genes in mouse, human and chicken.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: PCK1 polyclonal antibody detects endogenous levels of PCK1 protein.
Bioworld Molecular Weight: 69 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: ICC staining PCK1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining PCK1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: PEPCK-C, PCK1, PEPCK1, cytosolic [GTP], GTP, PCK1, PCKGC, PEP carboxykinase, PEPCK-C, PEPCK1, PEPCKC, Phosphoenolpyruvate carboxykinase 1 (soluble), Phosphoenolpyruvate carboxykinase 1, Phosphoenolpyruvate carboxykinase, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], Phosphoenolpyruvate carboxykinase, cytosolic, Phosphoenolpyruvate carboxylase, Phosphopyruvate carboxylase,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified