PCSK5 rabbit pAb - ES14196

PCSK5 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES14196-50, ES14196-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014],

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human PCSK5 AA range: 1507-1557

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 5125

Human SWISS Prot NO: Q92824

Subcellular Location: [Isoform PC6A]: Secreted. Secreted through the regulated secretory pathway.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

Research Use Only