PCSK9 Mouse Monoclonal Antibody (5G4) - RA11824

PCSK9 Mouse Monoclonal Antibody (5G4)

Size: 50μL, 100μL

Catalogue Numbers: RA11824-50, RA11824-100

Citations, Manuals and MSDS Available upon request.

Background: proprotein convertase subtilisin/kexin type 9 (PCSK9) Homo sapiens This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.84% sodium azide.

Storage Instructions: -20°C/1 year

Applications: IHC-p; WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 255738

Protein MW (KDa): 74

SWISS: Q8NBP7

Source: Mouse

Research Use Only