PCSK9 Rabbit Polyclonal Antibody - RA28591

PCSK9 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA28591-50, RA28591-100

Citations, Manuals and MSDS Available upon request.

Background: cofactor:Calcium.,disease:Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.,enzyme regulation:Inhibited by EGTA.,function:May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.,PTM:The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.,similarity:Belongs to the peptidase S8 family.,similarity:Contains 1 peptidase S8 domain.,subunit:The precursor protein but not the mature protein may form multimers.,tissue specificity:Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.,

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000

Alternative Names: Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9)

Applications: WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 255738

SWISS: Q8NBP7

Source: Rabbit

Research Use Only