Product Description

PD1 Monoclonal Antibody (Humanized)

Sizes: 50μl, 100μl

Catalogue Numbers: AP6666-50, AP6666-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The humanized monoclonal anti-PD1 antibody can effectively block the combination between PDL1 and PD1, and will not cause HAMA reaction (anti mouse antibody response). Programmed cell death protein 1 (PD-1) (UniProt Q15116), is a type I single transmembrane protein encoded by the PDCD1 gene in human. T-cell activation is generally self-limited as activated T cells express receptors such as PD-1. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 can bind two different but related ligands, PDL-1 and PDL-2.PD-1 receptor and its ligands PD-L1 and PD-L2play a vital role in the induction and maintenance of peripheral tolerance. The humanized monoclonal anti-PD1 antibody has demonstrated durable antitumor activity.

Category: Primary Antibody

Reactivity: Human

Host: Human

Applications: Neutralization/Block

Alternate Names: Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

Dilution: Neutralization/Block

Purification: Recombinant IgG antibodies were expressed and secreted by 293F cells and purified by Protein A.

Specificity: PD1 monoclonal antibody (Humanized) detects endogenous levels of human PD1 protein. Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

Molecular Weight: ~ 32 kDa

Pathway: Immune checkpoint signaling in the Tumor Microenvironment, Tumor-Infiltrating Immune Cell Marker Guide, T cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q15116

Product: 1mg/ml in PBS with 50% Glycerol.

Research Use Only