Product Description

PDE6G Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67455-50, BS67455-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterases) are important for the downregμlation of the intracellμlar evel of the second messenger cyclic adenosine monophosphate (cAMP), as they are responsible for hydrolyzing cAMP to 5'AMP. PDE6G, also designated phosphodiesterase 6G cGMP-specific rod g, is an oligomer composed of two catalytic chains (a and b), an inhibitory chain (g) and an d chain. PDEG6G functions in the processes of transmission and amplification of the visual signal. A mutation in the rod PDE-g gene desensitizes and delays murine rod photoreceptors. PDE6H, also designated phosphodiesterase 6H cGMP-specific cone g, is a tetramer composed of two catalytic chains (a and b) and two inhibitory chains (g). It functions similarly to PDE6H in vision processes. Defects of the PDE6H gene cause retinal cone dystrophy 3 (rcd3), also designated cone dystrophy with night blindness and supernormal rod responses.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Bovine, Dog

Host: Rabbit

Applications: WB

Alternate Names: PDEG, Retinal rod rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDE6G. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of PDE6G protein.

Molecular Weight: ~ 19 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P18545

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only