Product Description

PDE6G Polyclonal Antibody

Catalogue Numbers: BS67455-50, BS67455-100

Sizes: 50µl, 100µl

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P18545

Host: Rabbit

Reactivity: Human, Mouse, Rat, Bovine, Dog

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterases) are important for the downregulation of the intracellular evel of the second messenger cyclic adenosine monophosphate (cAMP), as they are responsible for hydrolyzing cAMP to 5'AMP. PDE6G, also designated phosphodiesterase 6G cGMP-specific rod g, is an oligomer composed of two catalytic chains (a and b), an inhibitory chain (g) and an d chain. PDEG6G functions in the processes of transmission and amplification of the visual signal. A mutation in the rod PDE-g gene desensitizes and delays murine rod photoreceptors. PDE6H, also designated phosphodiesterase 6H cGMP-specific cone g, is a tetramer composed of two catalytic chains (a and b) and two inhibitory chains (g). It functions similarly to PDE6H in vision processes. Defects of the PDE6H gene cause retinal cone dystrophy 3 (rcd3), also designated cone dystrophy with night blindness and supernormal rod responses.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of PDE6G protein.

Extra Notes: Western blot analysis of PDE6G expression in mouse eyes (A), rat eyes (B) whole cell lysates.

Bioworld Molecular Weight: ~ 19 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: PDEG; Retinal rod rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma; GMP-PDE gamma

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PDE6G. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified