PDHA1/2 (Phospho-Ser293/291) Rabbit Polyclonal Antibody - RA36809

PDHA1/2 (Phospho-Ser293/291) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36809-50, RA36809-100

Citations, Manuals and MSDS Available upon request.

Background: pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) Homo sapiens The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) . The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],

Condition: Liquid in PBS containing 50% glycerol, and 0.124% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5160

SWISS: P08559

Source: Rabbit

Research Use Only