Product Description

PDHA1/2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36705-50, RA36705-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1) Homo sapiens The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO (2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)

Clonality: Polyclonal

Dilution: WB 1:500-2000

Storage: -20°C/1 year

Human Gene ID: 5160

Human SwissProt Number: P08559

Condition: Liquid in PBS containing 50% glycerol, and 0.11% sodium azide.

Research Use Only