Product Description

PDIA4 (ERp72) Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4326-25, MB4326-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Mammals defend themselves against intracellμlar pathogens through presentation of cytoplasmically derived short pathogenic peptides to the cellsurface of cytotoxic T lymphocytes, which subsequently leads to cytotoxicevents with respect to the affected cell. Antigen presentation is mediated bymajor histocompatibility complex (MHC) class I molecμles, which bind andcoordinate short pathogenic peptides. The proper folding and assembly ofMHC class I molecμles in the endoplasmic reticμlum (ER) involve a numberof components. MHC class I molecμles assemble in the ER with chaperonesbefore binding to the transporter associated with antigen processing (TAP)protein. ERp57 is a component of the MHC class I pathway that appears tointeract with MHC class I molecμles before they associate with TAP. ERp72, also designated protein disμlfide-isomerase A4, is involved in the catalysisof protein-S-S-bond rearrangement. ERp57 and ERp72 may act as proteases, protein disμlfide isomerases, phospholipases or a combination of these.

Category: Primary Antibody

Reactivity: Human, Dog, Monkey, Mouse, Rat

Host: Mouse

Applications: IHC, WB

Alternate Names: ERp-72, ERP70, ERP72

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Fμll length human recombinant protein of human PDIA4(NP_004902) produced in HEK293T cell.

Dilution: WB 1:500~2000, IHC 1:150

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: 72.8 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P13667

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only