PDP1 Polyclonal Antibody - BT-AP12908

PDP1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP12908-20, BT-AP12908-50, BT-AP12908-100

Citations, Manuals and MSDS Available upon request.

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzy

Research Areas: Cancer; Metabolism; Signal transduction; Tags and cell markers

Target Protein: PDP1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q9P0J1; Mouse: Q3UV70; Rat: O88483

Synonyms: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial;PDP 1;EC 3.1.3.43;Protein phosphatase 2C;Pyruvate dehydrogenase phosphatase catalytic subunit 1;PDPC 1

GeneID: Human: 54704

Research Use Only