PE Rabbit anti-Human CD209/DC-SIGN Monoclonal Antibody
Sizes: 100T, 2 x 100T, 5 x 100T
Catalogue Numbers: A23593-100, A23593-200, A23593-500
Citations, Manuals and MSDS Available upon request.
Background: This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity.
Category: Monoclonal Antibodies
Application: FC
Cross Reactivity: Human
Protein Weight: 4kDa/18kDa/30kDa/33kDa/35kDa/37kDa/41kDa/43kDa/45kDa Immunogen: Recombinant protein (or fragment).
Species: Human
GeneID: 30835
SWISS: Q9NNX6
Alternate Names: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN
Source: Rabbit
Isotype: IgG
Purity: Affinity purification
Storage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Recommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Immunology Inflammation, CDs
NCBI Alias: CD209
Modifications: Unmodified
Conjugate: PE. Ex:565nm. Em:574nm.
Clone Number Info: ARC60195
Research Use Only