PEK/PERK rabbit pAb - ES8906

PEK/PERK rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8906-50, ES8906-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],

Alternate Name: Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK)

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human PEK/PERK Polyclonal

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 130kD

Human Gene ID: 9451

Human SWISS Prot NO: Q9NZJ5

Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Research Use Only