PEN2 Polyclonal Antibody-BS91050

PEN2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91050-50, BS91050-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9NZ42(Human) Q9CQR7(Mouse) O88777(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IHC FC

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
ICC:1:50-1:200
FC:1:50-1:100

Background: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: PEN2 polyclonal antibody detects endogenous levels of PEN2 protein.

Bioworld Molecular Weight: 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PEN2 on mouse spleen tissue lysate using anti-PEN2 antibody at 1/2,000 dilution., ICC staining PEN2 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: PSENEN, PEN2, MDS033, Gamma secretase subunit PEN 2, Gamma Secretase Subunit PEN2, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, MDS033, MSTP064, PEN 2, PEN2, Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, PSEN2, psenen,

Immunogen: Synthetic peptide corresponding to C-terminal human PEN2.

Conjugate: Unconjugated

Modification: Unmodified