PEN2/PSENEN Polyclonal Antibody Catalogue Numbers:BS76848-50, BS76848-100 Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: Q9NZ42 Host: Rabbit Reactivity: Human Applications: WB All Applications: WB,1:500 - 1:2000 Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. Specificity: Unmodification Note: For research use only, not for use in diagnostic procedure. Alternative Name: PSENEN;MDS033;MSTP064;PEN-2;PEN2 Immunogen: A synthetic peptide of human PEN2/PEN2/PSENEN(NP_758844.1). Conjugate: Unconjugated Modification: Unmodified